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In the reconstituted system, the direct consequence of PRC2.1 MTF2 dimer disruption by EPOP is the substantially weakened binding of linker DNA and nucleosome in vitro, which is also largely recapitulated by ChIP-seq in vivo in EpiLCs

Are other chronic diseases involved

36 , e22487 (2022)

125,139 Under chronic hyperglycemia, glycolysis becomes saturated, and excessive ROS are produced by alternative metabolic pathways to induce oxidative stress, causing mitochondrial and DNA damage