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However, DFP demonstrated inconsistent efficacy in other neurodegenerative diseases (Pandolfo et al., 2014)

Bioorg Chem 90:103073 Kretzschmar M, Mller D (1993) Aging, training and exercise

doi: 10.1038/s41590-019-0455-5 107 WangWZhengFLinCZhangA

Specifically, B12 is essential for: Fatty acid metabolism: It helps convert fatty acids into succinyl-CoA, which enters the Krebs cycle for ATP production

Molecules 26:4886 Mulholland CW, Strain JJ (1991) Serum total free radical trapping ability in acute myocardial infarction

Conversely, interventions that have combined IF with exercise have been proved feasible and suggest that participants are able to perform moderate- to high-intensity endurance or resistance exercise during extended periods of fasting (Reference Bhutani, Klempel and Kroeger32,Reference Kotarsky, Johnson and Mahoney67,Reference Moro, Tinsley and Bianco74)