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A portion of the NO synthesized by RBC eNOS can diffuse into surrounding tissues or be converted into nitrite under hypoxic conditions, supporting vasodilation and contributing to the regulation of blood flow in oxygen-deprived areas (LoBue et al., 2023)

The advancement of omics technologies such as multiplexed-scAEBS, scBS-Seq and single-cell ATAC-Seq have ushered in new opportunities for characterizing the epigenetic landscape of tumors and identifying resistance-associated factors

However, the lack of oxygen and substrates generally keeps ROS generation relatively lower compared to the subsequent phase

Chemiluminescence kinetic profiles KO 2 (80 M) was added into the CAR solution (20 M) in PBS (10 mM, pH = 7.4)