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To test cell excitability, depolarizing pulses (50, 100, 150 and 200 pA for 1 s) and ramps (from 0 to 100 pA within 2 s) were used to elicit action potentials (AP), with membrane potential initially held at 70 mV by injecting current

Changes in Synaptic Function, Bioenergetics, and Oxidative Metabolism Convergent evidence from imaging, neurochemical, and genetic studies points to disturbances in bioenergetics and mitochondrial function in the context of bipolar illness (268, 269)