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Long-term use of metformin and its effect on serum vitamin B12 with its oral manifestations: a review

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This is due to low absorption in the intestine, and breakdown by enzyme activity

The drug was been approved since 1959 and is used for the following indications: References Mechanism of Action 1,2 Phentermine predominantly acts in the central nervous system (CNS), within the hypothalamus and limbic systems, where it works on appetite regulation

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