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DNA was extracted using the QIAamp Fast DNA Stool Mini Kit (Qiagen) according to the manufacturers instructions

Pantothenic acid (Vitamin B5) is a water-soluble vitamin that helps maintain normal synthesis and metabolism of steroid hormones , vitamin D and some neurotransmitters, helps reduce tiredness and fatigue, and helps maintain normal mental function

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both of these promote melanogenesis and thus the characteristic mucocutaneous pigmentation [7, 12]

Effects of spermidine on gut microbiota modulation in experimental abdominal aortic aneurysm mice

Wang L, Jiao T, Yu Q, Wang J, Wang L, Wang G, Chen W (2021b) Bifidobacterium bifidum shows more diversified ways of relieving non-alcoholic fatty liver compared with Bifidobacterium adolescentis