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GSH is a major intracellular antioxidant compound, abundant in the cytoplasm, nucleus and mitochondria (39)

SL is an inhibitor of various hepatocellular tumours by inducing the pathway of Kip1/p27 messaging and inhibition of cyclins D1, D3 and E as well as cyclin-dependent kinases

[DOI] [PubMed] [Google Scholar] 420.Zhang YH, Zhang MH, Sears CE, Emanuel K, Redwood C, El-Armouche A, Kranias EG, Casadei B

The role of lysophospholipid metabolites LPC and LPA in the pathogenesis of chronic obstructive pulmonary disease

For future work, we plan to include more biological replicates, measure GST enzyme activity and glutathione redox status after RNAi, test combined knockdown of both genes, examine expression in other pine hosts and nematode populations, identify upstream regulators, and identify the specific substrates of these two GSTs

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