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, 1992), and neurodevelopment (Truman et al

All steps in these machineries are evolutionarily conserved from yeast to man

The liver uses this same system in bile acid synthesis and the hydroxylation of cholecalciferol to 25-hydroxycholecalciferol (vitamin D3;), and the kidney uses it to hydroxylate vitamin D3 to its biologically active 1,25-dihydroxylated form