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In addition, the Glu74 and Glu83 residues of ChaC2 are key for directing the conformation of the enzyme and regulating enzyme activity (20)

Research using cell culture models such as Calu-3 airway epithelial cells, has demonstrated that these cytokines affect the integrity and permeability of pulmonary epithelial barrier integrity by regulating key TJs proteins like occludin, claudin-2, and ZO-1

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This effect is attributed to its capacity to restrain the differentiation of CD4+ T cells producing IFN- and IL-17A, alongside reducing the synthesis of correlated cytokines like TNF-, IL-6, IL-17A, and IFN- in splenic cells