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But the new evidence, much of it in the last couple of years, is that vitamins also prevent the usual diseases we deal with every day-heart disease, cancer, osteoporosis, and birth defects

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Inhibition of PKC/ by auranofin increases SORLA levels, attenuates the SORLA-ARR2 interaction, and reduces amyloidogenic processing of APP in AD model mice Encouraged by our mechanistic studies demonstrating the critical role of the PKC/-ARR2 axis in disrupting the SORLA-retromer interaction and promoting SORLA lysosomal trafficking and degradation (illustrated in Fig

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It serves as a required substrate for enzymes such as sirtuins and poly(ADP-ribose) polymerases (PARPs). Sirtuins regulate cellular stress responses, metabolic homeostasis, and genomic stability, while PARPs play a central role in detecting DNA damage and initiating repair processes