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PMNR and RFBS contributed to writing of the original draft

Armen Nikogosian, MD Many autistic children struggle with chronic illness from a young age

Among the 83 included studies, 28 (44.4%) were considered high quality, 46 (55.4%) moderate quality, and 9 (10.8%) were of low quality (Supplementary Table S6), the main reason for low study quality was the absence of calculation of sample size (n = 82), no consideration of population stratification (n = 80) and lack of statistical correction for multiple testing (n = 53)