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Conservative treatments are often effective and may include: Anti-inflammatory medications to reduce pain and inflammation Rest and activity modification to relieve pressure on the sciatic nerve Ice or heat to relax tight muscles Injections such as steroid or platelet-rich plasma (PRP) to reduce pain and promote healing Physical therapy to correct muscle imbalances and restore normal function Surgical treatment may be considered if conservative measures fail: Decompression of the sciatic nerve Piriformis muscle release Neurolysis of the sciatic nerve Recovery from surgery typically takes several weeks to a few months, depending on the procedure performed and the individual patient

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While some have been subject to clinical studies, none have been approved as prescription drugs