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1 Introduction Multiple myeloma (MM) is a hematological malignancy characterized by the proliferation of terminally differentiated plasma cells in the bone marrow (BM) ( Pomalidomide is a second-generation immune-modulatory drug (IMiD) that is commonly used to treat patients with relapsed/refractory multiple myeloma (RRMM)

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A study (72) assessing the effects of resveratrol on metabolic parameters in ob/ob mice injected daily with resveratrol for 20 days or left untreated (as controls) showed that resveratrol: reduces testosterone reduces insulin levels reduced TNF- and IL-6 levels in adipose tissue In a rat model for PCOS (73), daily intraperitoneal injection of resveratrol for 4 weeks induced: a significant reduction in the number of antral follicle counts a significantly decreased plasma anti-Mullerian hormone and insulin-like growth factor 1 levels (playing a key role in PCOS metabolic disturbances) significantly lower superoxide dismutase activity significantly increased glutathione peroxidase which will reduce cell vulnerability to ROS