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10.1038/onc.2012.81 169 YanY.QingY.PinkJ

Novel Endogenous N-Acyl Amides Activate TRPV1-4 Receptors, BV-2 Microglia, and are Regulated in Brain in an Acute Model of Inflammation

& Santomasso, B

to inhibit ROS [93]

Kraus et al., Nature Medicine highlight that sustained NNMT inhibition drives metabolic changes, but strategic breaks may help preserve efficacy over time