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Both are effective at carrying long-chain fatty acids across the membrane into the mitochondria where they are burned for energy production and utilized efficiently by the cells.15-18 Acetyl-L-carnitine also guards against oxidative damage.5,19-21 Amyloid-beta peptide is a principal component of plaques and is thought to be a contributor to the aging process

Neutrophils serve as short-lived innate immune cells that constitute the first line of defense against microbial infections

The expression of Nrf2 was increased 3-fold in human GBM compared to that in normal brain tissue (67)

Future studies should incorporate patient-derived samples or clinical data to validate the therapeutic potential of HK2 and explore the mechanisms of HK2 by manipulating key genes or metabolites within the metabolic pathway to facilitate clinical application

doi: 10.1186/s13195-018-0458-8, 118

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