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Regulation of iron uptake, storage, intracellular trafficking, and utilisation is critical for maintaining cellular iron homeostasis [107]

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Variability in the results of the molecular imaging studies reviewed may be due to subject samples that may include individuals at risk for AD or who have subjective cognitive complaints, use of clinician rated or self-reported depression outcomes, how cognitive status or depression diagnosis was determined, number of past depressive episodes, antidepressant treatment history, how AD pathology was analyzed (a cutoff of positive/negative or whether quantitative measures were used)

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