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2 Materials and methods 2.1 Genome-wide association study data acquisition We obtained the GWAS dataset for 5-oxoproline levels (ebi-a-GCST90200280) from the GWAS Catalog, originating from the Canadian Longitudinal Study on Aging (CLSA) ( 2.2 Instrumental variables selection We employed a multi-step filtering approach to identify valid instrumental variables for genetic causal analysis

The next critical step in this research involves conducting in vivo studies to confirm neuroprotective activity, for example, using established mouse models

10.1176/ajp.156.5.675 Am

Some patients may be better suited to a different medical weight-loss strategy altogether

Lastly, certain limitations of the proteomics methods exist, including the size of proteoform detected by MS

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