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Apolipoprotein E (APOE), the primary apolipoprotein and cholesterol transporter in the central nervous system (Chen et al., 2021d), drives lysosomal cholesterol sequestration in astrocytes, reducing lipid catabolism and cholesterol transport, leading to lipid dyshomeostasis and impaired A clearance (Jeong et al., 2019)

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The phospholipase A(2) activity of Peroxiredoxin 6

10.1073/pnas.96.8.4524 118

S-nitrosoglutathione increases cystic fibrosis transmembrane regulator maturation

After washing with Dulbecco's phosphate-buffered saline (DPBS), cells were incubated in DPBS containing 2 M Calcein-AM for 30 min at 37 C