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Oral systemic therapies, including methotrexate, cyclosporine, acitretin, and apremilast, remain integral to psoriasis management, particularly for patients with moderate-to-severe disease who cannot afford biologic therapy

Significant amounts of orally ingested bromelain have been found to be absorbed into the bloodstream unchanged, thereby increasing the proteolytic and fibrinolytic blood activity for hours

A single dose of RBC@SeMSN@Uri maintained a UA-lowering effect for up to 48 h, while free uricase lost its effectiveness within 24 h (Figure 5B)

Further investigation revealed minimal impact of Tripterygium wilfordii on NLRP3/caspase-1 levels in MPTP-treated Nrf2-KO mice, suggesting that the extract may exert its anti-PD effects by activating Nrf2 to subsequently inhibit the NLRP3 inflammasome (Figure 4)

Jaworski K, Sarkadi-Nagy E, Duncan RE, Ahmadian M, Sul HS

Forbes SC, Candow DG, Little JP, Magnus C, Chilibeck PD