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Knockdown of LncRNA DLX6-AS1 inhibits HK-2 cell pyroptosis via regulating miR-223-3p/NLRP3 pathway in lipopolysaccharide-induced acute kidney injury

Immune cellsparticularly lymphocytes and macrophagesmaintain high intracellular GSH concentrations to sustain proliferation and cytokine production

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However, melatonin significantly counteracted these effects by reducing iNOS mRNA and protein levels, as well as NO production (Escames et al., 2003)

This underscored the principle that reducing hematoma expansion alone may be insufficient without addressing secondary injury cascades

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