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ROS elimination regulator: Nrf2 In addition to their direct role in ROS production and oxidative stress induction, AGEs can also perturb the balance of oxidationreduction by impacting the antioxidative stress system

This is especially important for tissue repair and new cell growth

Additionally, findings revealed that grape seed extract inhibited the phosphorylation of proteins such as ERK, JNK, and P38 in human epidermal keratinocytes subjected to UVB irradiation, suggesting its ability to suppress the MAPK signaling pathway and consequently reduce UVB-induced collagen degradation (60, 76)