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Their main adverse effect is skin atrophy, which manifests clinically as epidermal thinning, telangiectasia, spontaneous striae, fissuring, and hypertrichosis ( In summary, the BHG exhibits excellent biocompatibility and potent antibacterial activity, effectively reducing serum levels of IL-4, IL-13, IgE, and histamine in AD mice, and alleviating clinical symptoms including erythema, exudation, crusting, and pruritus

During the last decade, evidence has been obtained regardless of safety, validity and efficacy in large prospective clinical studies (Antonini et al., 2018)

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2014;9(10):e110056

L., Krienen, F

Aside from this, you can also apply Vitamin K cream directly to the bruise