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Intranasal administration of self-oriented nanocarriers based on therapeutic exosomes for synergistic treatment of Parkinsons disease

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Weighted gene co-expression network analysis (WGCNA) First, the WGCNA R package was used to construct a weighted gene co-expression network

Considering that this compound has been demonstrated to expand the GSH system along with a reduction in oxidative injury by the AKT/Nrf2 signaling pathway in the hearts of rats and H9C2 cells, the abovementioned enhanced TAC may cover GSH and GSH-dependent antioxidant enzymes [150152]

This creates a feed-forward cycle: impaired autophagy and ELS function lead to defective mitophagy, which allows the persistence of damaged mitochondria that, in turn, generate inflammatory DAMPs