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Transcriptional change in a cultured cell line is a hypothesis-generating observation

Subsequent gene-expression analyses cited in the review identified GHK-Cu as modulating expression of approximately one-third of human genes, with a pattern consistent with reversal of age-related transcriptomic shifts

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This mechanism is largely route-independent at the cellular level, which is why it is invoked for both topical and injectable use but a shared mechanism does not by itself prove that either route produces a visible skin outcome

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