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Among the 36 quinazoline derivatives, compounds 5, 6, 7, 8,9,10, 11, 12, and 13 ( 3745 ) showed potent inhibitory activity against DNMT3A with an IC 50 of 2.4, 1.1, 1.1, 2.7, 1.9, 1.1, 1.0, 2.6, and 1.4 M, respectively (Figure 8)

Indication 3: Treatment of HRS Indication 3: Treatment of HRS Hepatorenal syndrome (HRS) is a serious complication of progressive liver disease involving a complex interplay between circulatory dysfunction, renal physiology, and systemic inflammation

Bai Y, Han T, Dong Y, Liang C et al (2024) GPX8 + cancer-associated fibroblast, as a cancer-promoting factor in lung adenocarcinoma, is related to the immunosuppressive microenvironment

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Notably, microglia play a role in synaptic remodeling and contribute to brain development within the nervous system (40, 41)