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It was demonstrated that cystine deprivation can alter the phenotype of TNBC cells, as cystine deprivation instigated the development of necroptosis and ferroptosis in TNBC cells, and triggered mitochondrial fragmentation and reactive oxygen species (ROS) production (28)

10.1038/oncsis.2017.59 38 DongZ.ShanmughapriyaS.TomarD.SiddiquiN.LynchS.NemaniN.et al

The authors acknowledge funding from the National Health and Medical Research Council (NHMRC), Australia, awarded to B.N., E.G.B

The majority of these belonged to the following classes: carboxylic acids and derivatives, prenol lipids, benzene and substituted derivatives, and fatty acyls

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However, no significant difference in tumor weight was observed between the 5-FU and 5-FU + CT groups