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The hypersensitivity is thought to be mediated by immunoglobulin E (IgE) or sensitization to the vitamin B12 molecule itself

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[DOI] [PMC free article] [PubMed] [Google Scholar] 180.Ritonja J.A., Aronson K.J., Flaten L., Topouza D.G., Duan Q.L., Durocher F., Tranmer J.E., Bhatti P