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It is therefore an object of the invention to provide for a safe, effective and versatile approach for carrying cargo such as small molecules, peptides, proteins and nanocontaines (such as liposomes) containing drugs and genes across the cell membrane and across a blood-tissue barrier such as the blood-brain barrier for inter alia CNS drug targeting using glutathione transport receptors

Additionally, the expression of SLC7A11 decreased, which is another factor contributing to ferroptosis sensitivity

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A repetition time of 1.6 s was used for recovery of longitudinal magnetization between scans, and a number of 128 accumulations was set, resulting in a total measurement time of 14 min

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