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A wide-mouthed bottle is easier to fill with water, either at a fountain or beneath a spout

J Inherited Metab Dis 20 : 301306

In the inactive resting G complex, the G subunit is bound to the guanine nucleotide, guanosine diphosphate (GDP), but when a GPCR is activated, the receptor can catalyze a nucleotide exchange reaction on the G subunit (Fig