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FIGURE 2 Despite the immense potential of CAR-T cells, they carry risks such as on-target/off-tumor toxicity

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The carboxy-terminal domain is predicted to fold into a globular structure that forms a tight intramolecular association with the amino-terminal MABP-DENN domain module

For instance, mice with genetic deletion in glutamate transporter-1 exhibit reduced glutamate clearance, and consequently display abnormal cell death in motor neurons, reminiscent of amyotrophic lateral sclerosis (Staats and Van Den Bosch, 2009)

Tretinoin can often cause dryness, peeling, and sensitivity, especially during the initial stages of treatment

P., Lund, F