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Bhutiani N, Chiang YJ, Uppal A, Konishi T, White M, Vauthey JN, Kopetz S , Overman MJ, Chang GJ, Tran Cao H

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In terms of adverse reactions, no significant differences were observed between treatment and placebo groups, implying that ALC is generally well-tolerated

Quality assessment Appendix: Table S2 presents the risk of bias of included RCTs for each outcome

LTB4 is a lipid mediator derived from arachidonic acid by the sequential action of 5-lipoxygenase (5-LOX), 5-lipoxygenase-activating protein (FLAP) and LTA4 hydrolase (LTA4H) to stimulate leucocyte functions such as cytokines, chemokinesis, lysosomal enzyme release, superoxide anion production, adhesion to endothelial cells, generation of ROS and so on