chac1 glutathione CHAC2 is essential for self-renewal and maintenance in human embryonic stem cells Calcium channel mutants rescue the

Calcium channel mutants rescue the effect of glutathione depletion. (A) Download Scientific Diagram L 2 Hydroxyglutarate sensitizes ferroptosis through ATF3 CHAC1 mediated glutathione degradation in hepatocellular carcinoma Cell Death & Disease A scheme of the mechanism of CHAC1 degradation of glutathione enhancing Download Scientific Diagram Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF CRE Regulatory Element* Journal of Biological Chemistry The CHAC1 inhibited Notch3 pathway is involved in temozolomide induced glioma cytotoxicity ScienceDirect Mammalian proapoptotic factor ChaC1 and its homologues function as glutamyl cyclotransferases acting specifically on glutathione EMBO Reports Springer Nature Link

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