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Obwohl reduziertes Glutathion als Coenzym (Selen-abhngige Glutathion-Peroxidasen) und als Cofaktor (Glutathion-S-Transferasen) sowie auch als nicht-enzymatischer Scavenger und nukleophile Substanz in der Lage ist, direkt elektrophile Xenobiotika als primre oder sekundre Radikale sowie solche Radikale zu detoxifizieren, die im Zellstoffwechsel durch Exposition gegenber energiereichen Strahlen entstanden sind, kann es bei alleiniger therapeutischer Anwendung von reduziertem Glutathion - auch bei ausreichender Applikation desselben - zu Mangelzustnden kommen

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