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Topical formulations require penetration enhancers or vehicle optimization, and in vivo data suggest lower bioavailability compared to subcutaneous administration

The development of more potent and selective glutaminase inhibitors and effective delivery strategies remains an active area of research

Vitamins, carotenoids, polyphenols, melatonin, caffeine, N-acetylcarnosine and N-acetylcysteine are strong antioxidants that target oxidative stress in the pathogenesis of cataracts (19,28,107,118,132,145,176)

Inflammation control supports smoother recovery progression after injury (joint stress, tendon irritation)

Nrf2 is the transcription factor regulating the expression of antioxidant proteins engaged in the protection of cells and tissues against oxidative damage [7]

The fibrosis stage on the second biopsy correlated with the initial KC iron score (=0.27