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The right comparison depends on what the protocol is built around

Atherogenicity of amino acids in the lipid-laden macrophage model system in vitro and in atherosclerotic mice: a key role for triglyceride metabolism

Mice lacking one of the alleles of the COQ7 gene ( mCOQ7/mCLK1 gene ) show extended longevity even though their CoQ levels are the same as wild-type mice, suggesting that a factor other than CoQ per se may be responsible for lifespan extension in these animals (Lapointe and Hekimi, 2008)

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A recent study compared gut barrier dysfunction in patients with MASLD and ALD and reported more abnormalities in early stage of MASLD than in ALD (120)