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The outer membrane protein TbpA and the surface lipoprotein TbpB work together to extract iron from human transferrin, with TbpA forming the channel for iron transport across the membrane and TbpB acting as an initial binding partner that enhances iron release and transferrin removal

10.1016/j.jtemb.2022.127061 229 ZhangM.LiaoX.JiG.FanX.WuQ

The prevalence of NAFLD has increased rapidly over the last two decades, in parallel with the dramatic rise in obesity and diabetes

The primary mechanism involves the inactivation of GPX4, leading to lipid peroxidation and excessive ROS accumulation, which ultimately results in ferroptosis 39,40

R.Van PoeckeR

Glutathione acts as a frontline defender, neutralising reactive oxygen species (ROS) that damage collagen, elastin, and DNA