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In PTC tumors, the BRAF V600 E mutation has been shown to be positively correlated with mTOR pathway activation and upregulation 21

Additionally, the spike in testosterone has not shown to last over a sustained period and can be totally absent with chronic nicotine use

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Key pathways such as PI3K/AKT/mTOR (PAM), RAS/RAF/MEK/ERK [22], and Notch are frequently activated in GBM, promoting cell proliferation, survival, and invasion, while also contributing to the resistance of GBM cells to chemotherapy and radiation therapy

10.3390/ijms24043735 23 Estolano-CobinA.AlonsoM