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Chronic Fatigue Syndrome (ME/CFS) : Mold is a leading cause of mitochondrial dysfunction

Although the mechanisms are not completely clarified, EGF and PDGF receptors are activated in the presence of ROS, stimulating Ras and the consequent activation of the ERK pathway (91)

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Similarly, combined analysis of the 165 ROS-associated genes with the 3352 downregulated DEGs revealed 22 candidate ROS-associated downregulated DEGs in COAD, including LRPK2, TLR6, CYBB, ATP7A, HIF1A, CD36, CYP1B1, P2RX7, NOX4, TLR2, SH3PXD2A, BCL2, AGTR1, FBLN5, PDK4, THBS1, ITGAM, PDGFRB, EDN1, LEP, SFTPD, and MAPT

With three ubiquitinases, ubiquitin is bound to the lysine residues of substrate proteins and consumes ATP as energy

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