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Several reports describe that exenatide and GLP-1 analogs with higher molecular weight (through linkage with fatty acids and/or carrier proteins) can directly access the brain, especially the hypothalamus (70, 71)

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However, standard clinical practice in peptide therapy uses milligram-range dosing (12 mg) to achieve meaningful systemic concentrations

In vivo silencing of the Ca(V)3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathy