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Elevated E2F1 inhibits transcription of the androgen receptor in metastatic hormone-resistant prostate cancer

Compared with diabetes-induced rats, animals with diabetes had significantly lower daily sperm production (DSP), luteinizing hormone (LH) levels, follicle-stimulating hormone (FSH) levels, and testosterone levels, whereas animals administered seed extracts of Mucuna pruriens showed significant improvements in sexual behavior, libido and potency, sperm parameters, DSP, and hormone levels [41]

These dysfunctions are collectively regulated by metabolites, transport proteins, receptors, and enzymes

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The most synergistic effect was observed in the combination of 1 M of cisplatin and 5 M of 19 (CI = 0.235)