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In this study, microbial richness, assessed by Chao1 and ACE indices, was significantly reduced across all CHD subtypes compared to controls, with the most marked decrease in ACS patients

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CNS Drugs 25(12):9991007 Matsumoto K, Horie S, Takayama H, Ishikawa H, Aimi N, Ponglux D et al (2005) Antinociception, tolerance and withdrawal symptoms induced by 7-hydroxymitragynine, an alkaloid from the Thai medicinal herb Mitragyna speciosa