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While it is often marketed as having superior systemic bioavailability, clinical data actually shows that ALCAR has a lower overall accumulation in blood plasma compared to LCT

It is a non-essential amino acid that can be synthesized in the body

In liver cirrhosis, TRP supplementation could result in a marked increase in the TRP to BCAA ratio, resulting in anorexia and poor nutritional status due to increased serotonin formation and impaired BCAA transport into the brain and muscles [29,35,36]