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Furthermore, several studies demonstrated limitations in intervention implementation and adherence monitoring, attrition during follow-up, and handling of missing data, such as failing to clarify missing mechanisms or apply intention-to-treat analysis

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As a result, regular physical exercise could be useful as a non-invasive approach of inducing the endogenous expression of neurotrophic factors, which ultimately induce neurogenesis

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Site choice may depend on the treatment goal, tissue condition, patient comfort, and clinical judgment