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Under oxidative stress, PARP-1 activation leads to the consumption of nicotinamide adenine dinucleotide (NAD+) and adenosine triphosphate (ATP), resulting in cellular energy metabolism dysfunction

Cegarra L, Colins A, Gerdtzen ZP, Nunez MT, Salgado JC

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doi: 10.3389/fphys.2022.837001 [DOI] [PMC free article] [PubMed] [Google Scholar] 352

When the compounds being compared are structurally related but mechanistically distinct, sourcing quality and consistency become study design variables in themselves

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