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Saudi J Biol Sci 2014

Catalase-Related Diseases Catalase deficiency or malfunctioning is associated with many diseases such as diabetes mellitus, vitiligo, cardiovascular diseases, Wilson disease, hypertension, anemia, some dermatological disorders, Alzheimer's disease, bipolar disorder, and schizophrenia [2426] (Figure 5)

These results could be explained because of a defect in mitochondrial biogenesis processes, which would result in aberrant mitochondria, thus, contributing to the pathophysiology of AD, as already demonstrated in previous studies where mitochondrial biogenesis markers such as PGC-1a are reduced (Sheng et al., 2012)

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4B), accumulated following both pharmacological and genetic inhibition, confirming effective blockade of DHODH activity (Fig

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