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Vitamin C is a vital cofactor to the formation of collagen, the connective tissue that supports arterial walls, skin, bones, and teeth

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DOI: 10.3920/BM2022.0048

To that end, an E3 ligase activity-deficient mutant of UBR5 was generated by mutating the critical residue cysteine 2768 to alanine (UBR5C2768A, Mut-UBR5), as previously reported 39