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In contrast, drugs that remain largely unbound in plasma are generally available for distribution to other organs and tissues

Expression and characterization of Cys374 mutated human actin in two different mammalian cell lines: impaired microfilament organization and stability

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Key limitations of the existing evidence include: Small sample sizes in many studies Heterogeneous patient populations Variable dosing regimens (typically 35 grams daily) Short follow-up periods (often 4-12 weeks) Inconsistent outcome measures Potential publication bias favouring positive results Some studies have investigated combination approaches