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At 100+ pounds of loss, the skin has been dramatically stretched for years and the damage to collagen and elastin networks is more extensive

You dont want to just be in the reference range, the optimal range for B12 is much higher and ideally, you want to be above 400, and there does not seem to be an upper limit or toxicity from high Vitamin B12 levels

Pregnant or nursing mothers, children under 18, and individuals with known medical conditions should consult a physician before using Trim or any dietary supplement

That pulse pattern can be important for things like ovulation timing