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The studies are small, and proponents of the technique are quick to point to issues with the negative trials: the patients had severe symptoms and had failed to respond to any treatment, so we shouldnt generalize, and the measurements done to document improvement may not be accurate

Given the substantial behavioral variability characteristic of ASD, insufficient sample sizes represent an important source of bias in preclinical studies

In adults, especially those with delayed treatment during childhood, thromboembolic events such as DVT, PE and stroke frequently predominate, even in the absence of known risk factors

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