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Individuals with certain health conditions, such as Lebers disease (a rare inherited eye disease), should avoid B12 supplements as it can worsen the condition

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Chambers RC, Leoni P, Kaminski N, Laurent GJ, Heller RA: Global expression profiling of fibroblast responses to transforming growth factor-beta1 reveals the induction of inhibitor of differentiation-1 and provides evidence of smooth muscle cell phenotypic switching

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